KMID : 1023120150130060813
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Korean Journal of Aesthetic Society 2015 Volume.13 No. 6 p.813 ~ p.818
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Protective Effects of ¥á-Mangostin on UVB-induced Oxidative Stress and Cellular Senescence
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Ko Jung-Min
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Abstract
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One of subtypes in ultraviolet (UV), UVB, has been reported that the most powerful factors causing photoaging and DNA lesions. Finding and developing both cost-effective and efficient materials are the urgent issues to protect the skin from UVB-induced damages. Alpha-mangostin (¥á-mangostin), the first xanthone isolated from Garcinia mangostana (mangosteen), has been studied for anti-inflammation and antioxidant properties. The purpose of this study to investigate effects of ¥á-mangostin in HaCaT, keratinocyte against UVB radiation. To evaluate effects of ¥á-mangostin upon UVB-induced cytotoxic damages, watersoluble tetrazolium salt (WST-1) assay, flow Cytometry analysis, qunatitative real-time PCR (qRT-PCR), and senescence associated ¥â-galactosidase assay (SA-¥â-gal assay) were performed. Pretreatment of ¥á-mangostin was verified protective effects on UVB-induced proliferative restrain, apoptotic cell death and senescence, in HaCaT keratinocytes. These results indicated the protective effects of ¥á-mangostin against UVB, and suggest as a cosmeceutical ingredient.
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KEYWORD
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¥á-Mangostin, Ultraviolet B, Keratinocyte, Senescence, Oxidative stress
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